| Project Title |
| Generative classifiers and causal image labelling for safer, better medical AI |
| Systemic immune adaptation to menstruation: Defining the role of bone marrow in endometrial repair |
| Development of an Embryonic Chick Model for In Vivo Study of Human Congenital Cataracts |
| How can anti-tumoral neutrophil populations be harnessed to prevent disease progression in non-small cell lung cancer? |
| Co-produced solutions for low use of public access defibrillators following Out of Hospital Cardiac Arrest (OHCA) in deprived urban communities in Scotland. |
| Mechanisms of epileptogenesis and therapeutics in a rat model of DEPDC5-related epilepsy |
| Characterising the circulating neutrophil compartment of preterm infants and its association with sustained innate immune dysfunction |
| Characterising the role of the WRN gene as a tumour suppressor in high grade serous ovarian cancer |
| Role of Neutrophils and Macrophages in the Resolution of Microbial Keratitis |
| A data driven approach to explore the impact of distinct clinical phenotypes on end-organ dysfunction and longer-term outcomes of ICU patients |
| Integration of the physical environment and blood-based multi-omics to explore life-course risk factors for brain health |
| Understanding and improving pregnancy planning and prevention in a high HIV burden setting |
| PGK1 as a target for therapeutics in Motor Neuron Diseases |
| Investigating interactions between co‐infecting nematodes and host immunity using meta‐analytic, observational and experimental approaches |
| Defining the hypoxia-induced changes in chromatin organisation during reprogramming and pluripotency maintenance |
| Understanding the Impact of Obesity on Adipose Tissue B Cells in the Context of Type 2 Diabetes |
| Engineering the Production of Thymic and Splenic Tissue in vitro |
| Understanding HIV drug resistance through sequence data analysis and mathematical modelling |
| The role of efferocytosis in regulating inflammatory macrophage fate and response to injury in the peritoneal cavity |
| The role of FAK‐inhibition in antitumour T‐cell response in pancreatic cancer |
| Exploring mechanisms of neural crest function during development using in vitro, ex vivo and in vivo model systems |
| Survival and adaptation of viruses within respiratory droplets: a c ombined molecular biological an d biophysical study |
| Mechanisms underpinning the propagation of pathological tau in tauopathies |
| The role of ER-phagy in pancreatic tumour initiation |
| Investigating the importance of monocyte-macrophage immunometabolism in Inflammatory Bowel Disease |
| Exploring the “co mmunity effects” of NOTCH1 in early keratinocyte tumorigenesis |
| Investigation into the role of α2β1 integrin in biliary morphogenesis and tissue homeostasis through cell‐matrix interactions |
| How does genetic variation at 19q13 impart elevated risk of colorectal cancer: the contribution of interaction between FUT2 gene expression and the composition of gut microbiome |
| The Influence Of Cholangiocyte Senescence And Its Senescence-associated Secretory Phenotype On Hepatocyte To Cholangiocyte Differentiation’ |
| Understanding how chromatin organisation facilitates DNA virus persistence and innate immune system evasion |
| DNA Damage As An Engine Of Genetic Diversification During Cancer Evolution |
| Investigation of the GPR56 ligand and intracellular signaling in Leukaemic stem cells |
| The role of neutrophil subpopulations in metastatic non‐small cell lung cancer (NSCLC) |
| Spatial regulation of core neurodevelopment transcription factors in human glioblastoma stem cells |
| How do dysfunctional endothelial cells in cerebral small vessel disease modulate surrounding oligodendroglia through secretion of heath shock protein 90 alpha? |
| Improving engraftment for cell therapy in cholangiopathies |
| Maximising T cell cytotoxicity and persistence for long term anti-cancer protection for use in adoptive cell therapy (ACT) |
| Establishing the role of Staphylococcus aureus RNA-binding proteins in regulating host adaptive responses and antibiotic resistance |
| Investigating the crosstalk between adipocytes and macrophages during wound repair |
| The effect of diabetes mellitus and glucose dysregulation on neutrophil function and preconditioning |
| Investigation of the Pro-Fibrogenic Macrophage Populations Driving Pulmonary Fibrogenesis Using a Single Cell RNA Sequencing Approach |
| Non-cell autonomous effects of microglial nuclear factor erythroid 2-related factor 2 signalling after intracerebral haemorrhage |
| Identification and characterisation of the TLR2-CASP4 mediated non-canonical inflammasome in non-small cell lung cancer |
| Understanding the role of DNA methylation as a determinant of organism size |
| Characterisation of RAC signalling in Inflammatory Bowel Disease-associated colorectal cancer |
| Investigating Streptococcus pneumoniae evolutionary adaptation to the macrophage to identify critical microbicidal mechanisms |
| Investigation of pro-regenerative mesenchymal subpopulations during liver regeneration using a single cell RNA sequencing approach |
| Mapping the targets of RNase MRP |
| CD97 in the host response to influenza |
| Investigating the genetic mechanisms of keratoconus |
| Maternal hyperglycaemia and fetal neurodevelopment |
| Establishing causal relationships from phenotypic, genotypic and proteomic data. |
| Genome embedded ribonucleotides: causes and consequences |
| The genetic and developmental basis of PAX6-negative aniridia |
| Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage |
| The role of central nervous system myelination in behaviour |
| Effects of FAK signalling on induction of Th17 cells in the tumour microenvironment |
| The effects of neuronal activity on astrocyte neuroprotective functions |
| Can interleukin-4 or interleukin-13 be harnessed to aid liver repair, regeneration & fibrosis regression? |
| The regulation of neutrophilic inflammation by Semaphorin3F |
| Investigation of host red blood cell receptors essential for rosetting in severe Plasmodium falciparum malaria |
| The role and modulation of innate immune cells in Inflammatory Bowel Disease |
| The allosteric regulation of glycolysis: a comparison of the phosphofructokinases of four species separated in evolutionary time |
| Can altered white matter tract characteristics predict cognitive outcome following paediatric epilepsy surgery? |
| The role of eosinophils in post-myocardial infarction cardiac remodelling |
| Investigation of the role of pericyte αv integrin-mediated TGFβ activation on vascular integrity and fibrogenesis during renal injury using a novel intravital imaging approach |
| Tracing the origin of the Wilms’ tumour stem cell |
| DNA modification profiling as a tracker for high fat diet and hyperglycaemia |
| Functional consequences of missense mutations in GRIN2A and GRIN2B associated with mental disorders. |
| How does the Swain-Langley 2 polymorphism in complement receptor 1 protect against cerebral malaria? |
| The role of the ATX/LPA signalling axis in the metastatic dissemination of lobular breast cancer |
| Analysis of the early development of human haematopoietic stem and progenitor cells |
| Exploration of Helminth-derived Immunoregulatory Molecules as Options for Cellular or Pharmacological Intervention in Transplantation |
| The role of epigenetics in the regulation of intestinal homeostasis and inflammation. |
| Rhodopsin trafficking defects in Retinitis Pigmentosa |
| Investigating the role of new genetic susceptibility loci in osteoarthritis |
| Why does R133C, a missense mutation in Methyl-CpG Binding Protein 2, cause Rett Syndrome? |
| Changes in chromatin structure during the response of macrophages to glucocorticoids |
| Designing and manipulating neurons cultured on parylene-C/SiO2: how does the functionality of micro-engineered poly-neuronal networks change in response to interrogation? |
| The Role of WT1 in adult angiogenesis |
| Unleashing the potential of pericytes: direct contact with endothelial cells inhibits the stem cell potential of pericytes. |
| Do small molecule activators of Wnt signalling enhance differentiation and elongation of mouse intestine? |
| Novel ligands for fluorescent imaging of breast and ovarian cancer in mouse models |
| Modulation of inflammatory cell apoptosis in infectious lung injury |
| Can mitotic kinases be exploited as drug targets in Oesophageal Adenocarcinoma? |
| Developmental Genetics Analysis of Post-Axial Transverse Limb Reduction Deformity (PATLRD) |
| The role of CDK11-mediated autophagy in tumour cells and the impact of dysregulation on tumorigenesis. |
| Comparative genomics of the inflammatory response. |
| The Src and FAK families of non-receptor tyrosine kinases in primary brain tumours. |
| Structural and functional changes in the distal convoluted tubules of the kidney in mouse models of hypertension. |
| WT1 in the kidney: Regulation of the epithelial - mesenchymal balance |
Please find below a list of ECAT PhD projects in reverse chronological order (most recent first).
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